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1 article(s) from García-Lacuna, Jorge

Inline purification in continuous flow synthesis – opportunities and challenges

Jorge García-Lacuna and
Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

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Graphical Abstract

Scheme 1: Automated in-line chromatography with the Advion puriFlash^® system. The rightmost part of the schem...

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Scheme 2: Purification via pH tuning and several Zaiput membranes. Redrawn from [51].

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Scheme 3: Two-phase recirculating system for purifications of an immobilized enzyme-based reaction. Redrawn f...

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Scheme 4: Countercurrent L–L purification using large Zaiput membranes in the presence of a phase transfer ca...

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Scheme 5: General scheme of a telescoped flow process using L–L separators.

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Scheme 6: Example of phase separation using a computer-vision approach. Redrawn from [68].

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Scheme 7: Example of an inline purification using heterogeneous scavenging. Redrawn from [76].

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Scheme 8: General scheme of a telescoped process using heterogenous cartridges.

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Scheme 9: Comparison of two strategies for flow-based imatinib syntheses. Redrawn from [91] and [92].

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Scheme 10: General purification scheme using the catch and release strategy.

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Scheme 11: Exemplar catch and release purification of a stereoselective oxidation. Redrawn from [105].

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Scheme 12: Catch and release-type purification using conventional SiO₂. Redrawn from [107].

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Scheme 13: Schematic representation of an industrial continuous crystallization. Redrawn from [109].

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Scheme 14: General scheme of an academic inline crystallization approach.

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Scheme 15: Simplified overview of purification options and selected criteria.

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Published 16 Dec 2022

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